Wednesday, December 16, 2009

WTF?!

Another apocalyptic sign...

Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with 'exercise mimetics'.

Carey AL, Kingwell BA.
Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia.
andrew.carey@bakeridi.edu.au

Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the primary strategy, but these are of limited long-term efficacy because of failure to maintain behavioural change. An alternative approach used to elicit the benefits of exercise training and overcome the problems of long-term compliance is to develop drugs that mimic aspects of the trained state. Elucidation of metabolic pathways responsive to exercise in various tissues, particularly skeletal muscle, was an important antecedent to the promising concept of drugs that may mimic specific aspects of the exercise response. From an obesity perspective, an important aim is to develop an agent that reduces body fat and improves metabolic homeostasis. This review focuses on promising metabolic signalling pathways in skeletal muscle that may yield 'exercise mimetic' targets.

PMID: 19547950 [PubMed - indexed for MEDLINE]

Like everything else; there's money to be made.

"C'mon Man."

Move.
AS

6 comments:

jleeger said...

Aaron...the idea that we can manipulate "variables" is a dangerous idea...

Read the Booth/Laye paper, where they annihilate the idea of an "exercise mimetic."

http://www.ncbi.nlm.nih.gov/pubmed/19723782

Aaron Schwenzfeier said...

Dangerous indeed.

I read it... excellent article.

Mike T Nelson said...

Yes, it was good to see a nice reply to that article.

Big pharma is still thinking in the box and has been trying to do that concept for years since they know exercise fixes almost ALL diseases!

Go move! :)

Rock on
Mike T Nelson PhD(c)
Extreme Human Performance

Aaron Schwenzfeier said...

Very true Mike.

The answers are so simple, but they require the rarest of qualities.

Dustin S. said...

I like that Aaron, "The answers are so simple, but they require the rarest of qualities."

Steve said you were in town, if you get a chance next time stop by, would be great to talk!

オテモヤン said...

オナニー
逆援助
SEX
フェラチオ
ソープ
逆援助
出張ホスト
手コキ
おっぱい
フェラチオ
中出し
セックス
デリヘル
包茎
逆援
性欲