|No, that is not a hammock in North Dakota|
Research out of neuroscience confirms similar aspects looking at neuroplasticity and attempts to reorganize cortical motor outputs. So not only might time off relegate peripheral systems but also activity centrally within motor cortex; The Plastic Human Brain Cortex.
This is also important in the sequencing of the microcycle, as not all situations are ideal and athletes may come back to train after a 2 day weekend in which some have probably been entirely 'off' (they may have been assigned recovery sessions but unless a coach is present, it would be ignorant to think it always gets done). In this case it may NOT be advisable to perform a "high" day like so many coaches do the first day in a training week; working fast or heavy or both and then tapering as the microcycle goes. I've tried to be very careful about performing intense speed and/or agility work after a full 2 days off. Instead it might be advisable to perform a "low" day to restart the systems, open up ranges of motion, and hormonally flush the system (i.e. purposeful circuits)... preparing for a "high" session the next day, while still getting quality training in. Injury prevention/reduction is about many things and not always about what is being done.
Many coaches focus on the macro-, meso-, and maybe to some extent the microcycles, but reality needs a close look; and there are many factors to consider in the world of chaos we live in. If "off" days are not or can not be filled with active recovery, then I need to be smart about what goes on when the athletes are in front of me.